Amoxil

1-Active Ingredient:
-amoxicillin

2-Concentration:
-Injections 250 mg – 500 mg – 1 g amoxicillin
-Capsules 250 mg – 500 mg amoxicillin
-syrup 125 mg amoxicillin
-syrup forte 250 mg amoxicillin
-pediatric drops 125 mg amoxicillin

3-Dosage form:
-Injections
-Capsules
-syrup
-syrup forte
-pediatric drops

4-Indication:
-respiratory tract infection
-ear, nose and throat infection
-urinary tract infection
-Gastro-intestinal infection
-enteric fever
-skin and soft tissue infection
-Biliary tract infection
-orthopedic infection
-pelvic infection
-gonorrhea
-syphilis
-septicemia
-endocarditis
-meningitis
-peritonitis
-dental abscess

5-Side effect:
-diarrhoea
-indigestion
-occasional rash
- erythematous rash

6-Contraindication:
It should not be administered in patients hypersensitive to penicillin


7-Precautions:
-during treatment with high doses an adequate fluid intake and urinary output must be maintained
-indwelling urinary catheters should be regularly checked for potency since high urinary concentration of some drug may precipitate out of solution

8-Dose:
*general recommendation:
Adult:
-oral / IM injection: 250 – 500 mg every 8 hours
-IV injection / infusion: 500 mg – 1 g every 4 – 6 hours
Children:
- Oral / IM injection: 125 mg three times daily increasing to 250 mg in severe infection.
Amoxil pediatric drops are recommended for children under 6 months: 35 – 100 mg/kg/day.
-IV injection / infusion: up to 100mg/ kg / day in divided doses every 6 hours by infusion over 30 minutes
*specific dosage recommendation:
-Typhoid and Paratyphoid:
Adults…….. 4 gm daily for 14 – 21 days
Children………100 mg / kg / day in divided doses for 14 – 21 days
-Typhoid carrier states …… 3 – 4 gm daily for a minimum of one month
-gonorrhea ……….. Single dose of 3 gm plus 1 gm probenecid
-uncomplicated urinary tract infection……… a single dose of 3 gm
-meningitis:
Adult ……. 150 mg / kg / day in equally divided doses
Children …..100 – 150 mg / kg / day in equally divided doses
-syphilis …….. 250 mg every 6 hours for 4 weeks up to 5 months
-sever or recurrent lower respiratory tract infection ……. 3 gm twice daily
-dental abscess …….. Two 3 gm doses with 8 hours between doses
-otitis media …… 750 mg twice a day used in children from 3 – 10 years

9-Over dose:
-Since it is a penicillin over dose problems are unlikely to be encountered
-Will produce very high urinary concentration
-Crystalluria is possible
- The antibiotic is removed by heamodialysis

10-Storage:
-store in dry place below 25 C
-once dispensed the syrups should be used in 7 days
-keep out of reach of children

11-Package:
-injection: vials containing 250 mg or 500 mg or 1 g amoxicillin
-capsules: box of 12 capsules
-syrup: bottle of 60 ml of 250 mg or 125 mg

12-produced by:
Beecham pharmaceuticals

13-Price:
-amoxil 500 capsules……. 7.00 L.E
-amoxil 250 suspension……5.50 L.E
-amoxil 125 suspension…….3.75 L.E
-amoxil 500 vial ……4.50 L.E
-amoxil 250 vial……..3.20 L.E