Rapamune

1-Active Ingredient:
Sirolimus

2-Concentration:
-oral solution contains 1 mg/ 1 ml Sirolimus
-tablet contains 1 mg or 2 mg Sirolimus

3-Dosage form:
-oral solution
-tablets

4-Indication:
For the prophylaxis of organ rejection in patients aged 13 years or older receiving renal transplants

5-Side effect:
-immunosuppresion
-increased susceptibility to infection and the possible development of lymphoma and the other malignancies, particularly of the skin
-over suppression of the immune system can also increase susceptibility to infection including opportunistic infection
-fatal infection
-sepsis
-deterioration of renal function (with long term admenstration)

6-Contraindication:
It’s contraindicated in patients with hypersensitivity to Sirolimus or its derivatives or any component of the drug product

7-Precautions:
*general
-its intended only for oral administration
-lumphocele occurred significantly more often in a dose related fashion in patients treated with rapamune so appropriate operative measures should be considered to minimize this application
*lipids
-rapamune use in renal transplant patients was associated with increased serum cholesterol and triglycerides that may require treatment
*renal function
Patients treated with cyclosporine and rapamune were noted to have higher erum creatinine levels and lower glomerular filtration rates compared with patients treated with cyclosporine and placebo or azathioprine controls.
*calcineurin inhibitor- induced hemolytic uremic syndrome
The concomitant use of Sirolimus with a calcineurin inhibitor may increase the risk of calcineurin inhibitor- induced HUS/TTP/TMA
*concomitant use of angiotensin- converting enzyme (ACE) inhibitors
In rare cases the concomitant administration of Sirolimus and ACE inhibitors has resulted in angioneurotic edema type reaction
*antimicrobial prophylaxis
-cases of pneumocystis crainii pneumonia have been reported in patients not receiving antimicrobial prophylaxis so it should be administered for a year after transplantation
-cytomegalovirus prophylaxis is recommended for 3 months after transplantation
*intestinal lung disease
Cases of intestinal lung disease, some fetal , with no identified infectious etiology have occurred in patients receiving immunosuppressive regimen sometimes it has resolved by discontinuation or dose reduction. The risk increase by increasing concentration
*pregnancy
- Sirolimus was embryo/feto toxic in rates at dosage of 0.1 mg/ kg
-embryo/feto toxicity was manifested as mortality and reduced fetal weight
*lactation
- Sirolimus is excreted in trace amounts in milk of lacting rats, it’s not known whether its excreted in human milk or not
-the safety profiles of Sirolimus in infants are not known
*pediatric use
-the safety and efficacy of rapamune in pediatric patients below the age of 13 years have not been established
*geriatric use
-clinical studies of rapamune oral solution or tablet didn’t include sufficient numbers of patients aged 65 years or over to determine whether safety and efficacy differ in this population from younger people.

8-Dose:
It is recommended that rapamune oral solution and tablets be used initially in regimen with cyclosporine and corticosteroid for 2 to 4 months after transplantation in patients at low to moderate immunological risk

9-Over dose:
General supportive measures should be followed in all cases of overdose based on the poor aquoues solubility and the high erythrocyte and plasma protein binding of Sirolimus, it is anticipated that Sirolimus is not dialyzable to any extent. in mice and rats the acute oral lethal dose was greater than 800 mg/kg

10-Storage:
*oral solution:
-should be protected from light
-Refrigerated at 2 – 4 C
-once the bottle opened the continents should be used within one month
*tablets:
-should be stored at 20-25 C-use cartons to protect blister cards and strips from light
-dispense in a tight light resistant containers

11-Package:
Tablets: box containing 10 strips each contain 10 tablets

12-produced by:
Wyeth pharmaceuticals

13-Price:
-oral solution: 169 £
-tablets: 90 £

Amoxil

1-Active Ingredient:
-amoxicillin

2-Concentration:
-Injections 250 mg – 500 mg – 1 g amoxicillin
-Capsules 250 mg – 500 mg amoxicillin
-syrup 125 mg amoxicillin
-syrup forte 250 mg amoxicillin
-pediatric drops 125 mg amoxicillin

3-Dosage form:
-Injections
-Capsules
-syrup
-syrup forte
-pediatric drops

4-Indication:
-respiratory tract infection
-ear, nose and throat infection
-urinary tract infection
-Gastro-intestinal infection
-enteric fever
-skin and soft tissue infection
-Biliary tract infection
-orthopedic infection
-pelvic infection
-gonorrhea
-syphilis
-septicemia
-endocarditis
-meningitis
-peritonitis
-dental abscess

5-Side effect:
-diarrhoea
-indigestion
-occasional rash
- erythematous rash

6-Contraindication:
It should not be administered in patients hypersensitive to penicillin


7-Precautions:
-during treatment with high doses an adequate fluid intake and urinary output must be maintained
-indwelling urinary catheters should be regularly checked for potency since high urinary concentration of some drug may precipitate out of solution

8-Dose:
*general recommendation:
Adult:
-oral / IM injection: 250 – 500 mg every 8 hours
-IV injection / infusion: 500 mg – 1 g every 4 – 6 hours
Children:
- Oral / IM injection: 125 mg three times daily increasing to 250 mg in severe infection.
Amoxil pediatric drops are recommended for children under 6 months: 35 – 100 mg/kg/day.
-IV injection / infusion: up to 100mg/ kg / day in divided doses every 6 hours by infusion over 30 minutes
*specific dosage recommendation:
-Typhoid and Paratyphoid:
Adults…….. 4 gm daily for 14 – 21 days
Children………100 mg / kg / day in divided doses for 14 – 21 days
-Typhoid carrier states …… 3 – 4 gm daily for a minimum of one month
-gonorrhea ……….. Single dose of 3 gm plus 1 gm probenecid
-uncomplicated urinary tract infection……… a single dose of 3 gm
-meningitis:
Adult ……. 150 mg / kg / day in equally divided doses
Children …..100 – 150 mg / kg / day in equally divided doses
-syphilis …….. 250 mg every 6 hours for 4 weeks up to 5 months
-sever or recurrent lower respiratory tract infection ……. 3 gm twice daily
-dental abscess …….. Two 3 gm doses with 8 hours between doses
-otitis media …… 750 mg twice a day used in children from 3 – 10 years

9-Over dose:
-Since it is a penicillin over dose problems are unlikely to be encountered
-Will produce very high urinary concentration
-Crystalluria is possible
- The antibiotic is removed by heamodialysis

10-Storage:
-store in dry place below 25 C
-once dispensed the syrups should be used in 7 days
-keep out of reach of children

11-Package:
-injection: vials containing 250 mg or 500 mg or 1 g amoxicillin
-capsules: box of 12 capsules
-syrup: bottle of 60 ml of 250 mg or 125 mg

12-produced by:
Beecham pharmaceuticals

13-Price:
-amoxil 500 capsules……. 7.00 L.E
-amoxil 250 suspension……5.50 L.E
-amoxil 125 suspension…….3.75 L.E
-amoxil 500 vial ……4.50 L.E
-amoxil 250 vial……..3.20 L.E

Tenolat SR

1-Active Ingredient:
-Nifedipine
-Atenolol

2-Concentration:
Each capsule contains:
-Nifedipine 20 mg
-Atenolol 50 mg

3-Dosage form:
-Capsules

4-Indication:
-All forms of hypertension including renal hypertension
-Angina (prinze metal’s angina, chronic stable angina)

5-Side effect:
-Gastrointestinal troubles
-Headache
-Tachycardia
-dizziness
-Fatigue
-Flushing
-Hypotension
-Peripheral oedema
-Hyperdiasis.

6-Contraindication:
-Sensitivity to Nifedipine and Atenolol
-Acute myocardial infraction
-Chronic obstructive airway disease


7-Precautions:
These may need control adjustment:
-Pregnancy
-Diabetes mellitus
-Acute heart failure

8-Dose:
-Hypertension: 1 capsule once daily
-Angina: 1 capsule twice daily
Or as prescribed



9-Over dose:
-Stomach should be emptied by aspiration and lavage
-Hypotension treated by laying the patient in supine position and feet raised
-standard measures (atropine for bradycardia – noradrenalin for hypotension)

10-Storage:
-Store at 25 C

11-Package:
-Pack of 20 capsules in 2 blisters

12-produced by:
SIGMA pharmaceutical industries

13-Price:
10 L.E

nilsid

1-Active Ingredient:
Nimesulide

2-Concentration:
-each tablet contains nimesulide 100 mg
-each 5 ml suspension contains nimesulide 50 mg
-each 100 g cream contains nimesulide 5 g

3-Dosage form:
-tablet
-suspension
-cream

4-Indication:
-painful inflammatory condition
-osteoarthritis
-rheumatoid arthritis
-ankylosing spondylitis
-acute gout
-painful musculoskeletal conditions
-toothache and after orodental surgery
-primary dysmenorrheal and other gynecological disorders
-conditions associated with fever

5-Side effect:
-mild gastrointestinal disturbances
-skin rashes (rarely)

6-Contraindication:
-hypersensitivity to nimesulide
-active peptic ulcer
-sever hepatic or renal impairment
-pregnancy

7-Precautions:
It should be used with cautious in patients with history of
-peptic ulcer
-ulcerative colitis
-crhon’s disease

8-Dose:
-Tablets and suspension:
Adults: one tablet or 10 ml suspension twice daily or as prescribed


Children: ½ - 1 teaspoonful twice daily or as prescribed
-Cream: apply sufficient amount of the cream to the affected area of the skin with gentel rubbing 3 – 4 times daily

9-Over dose:
………………….

10-Storage:
-keep at a temperature (15 – 30 C)
-keep out if reach of children

11-Package:
-tablets: box containing 10 or 20 tablets
-suspension: bottle containing 120 ml suspension
-cream: tube containing 20 g cream

12-produced by:
Pharaonia Pharmaceuticals

13-Price:
-tablet: 9.00 L.E
-suspension: 6.00 L.E
-cream: 4.50 L.E

neurovit

1-Active Ingredient:
-thiamine HCL (vitamin B1)
-pyridoxine HCL (vitamin B6)
-cyanocobalamine (vitamin B12)
2-Concentration:
-thiamine HCL (vitamin B1) …………. 250 mg
-pyridoxine HCL (vitamin B6)…………100 mg
-cyanocobalamine (vitamin B12)……….250 mcg
3-Dosage form:
Sugar coated tablets

4-Indication:
-metabolic disorder
-anemia
-peripheral neuritis
-demyelination and other neurological disorders
-chronic and acute beri-beri
-Improvement of fat - carbohydrate – amino acid metabolism
-depletion or increased demands of vitamin B1 , B6 or B12

5-Side effect:
……………………

6-Contraindication:
Not known

7-Precautions:
………………….

8-Dose:
1 – 3 tablets daily or as prescribed

9-Over dose:
………………

10-Storage:
-store at 25 C

11-Package:
A box containing 2 strips 10 tablets each

12-produced by:
European Egyptian pharmaceuticals

13-Price:
6.00 L.E

NATRILIX - SR

1-Active Ingredient:
-Indapamide

2-Concentration:
-Each tablet contains 1.5 mg indapamide

3-Dosage form:
-Sustained release tablets

4-Indication:
-Essential hypertension

5-Side effect:
-Fatigue
-Allergic manifestation
-Skin rash
-Feeling of vertigo when changing from lying to standing position
-Dehydration (elderly)
-Heart failure (elderly)
-Variation in blood parameters

6-Contraindication:
This drug must not be taken when:
-Known allergy to this drug or to sulphonadmides.
-Renal failure.
-Serious liver disease.
-Hypokalemia.

7-Precautions:
*Use cautiously when:
-Having disturbed water/ electrolyte balance
-diabetes
-gout
-kidney problems
*Pregnancy and lactation:
-Inform your physician if you are pregnant, breast feeding or trying to get pregnant.
*Drivers and machinery operators:
-Decrease in blood Pressure may occur so the ability to drive or use machines may be diminished.
*Athletes:
- It may induce a positive reaction during antidoping testes.

8-Dose:
One tablet per day preferably at morning

9-Over dose:
-Doctor must be consulted immediately
-Signs of acute poisoning in the form of water/ electrolyte disturbance
-Measures involve rapid elimination of the ingested substances by gastric wash-out or administration of activated charcoal followed be restoration of water/ electrolyte balance

10-Storage:
-Do not exceed the expiry date
-Should be protected from humidity
-Store at room temperature (15 – 25 C)
-Keep out of reach of children

11-Package:
-Box of 30 coated tablets

12-produced by:
Servier Egypt Industries Limited

13-Price:
11 L.E

callocure

1-Active Ingredient:
-Salicylic acid
-Lactic acid
-Flexible collodion

2-Concentration:
Per 10 gm
-Salicylic acid 1 gm
-Lactic acid 1.5 gm
-Flexible collodion 6.9 gm

3-Dosage form:
-Solution

4-Indication:
-For the removal of corns, warts weals and callus

5-Side effect:
………………..

6-Contraindication:
………………….

7-Precautions:
…………………..

8-Dose:
-Callus: twice a day directly on callus
-Corns: twice a day directly on corns
-Warts: twice a day directly on small to medium size warts

9-Over dose:
………………..

10-Storage:
-Store carefully
-Keep out of reach of children
-Close the bottle immediately after use

11-Package:
Bottle containing 10 ml with an easily use applicator

12-produced by:
Mash company for pharmaceutical industries

13-Price:
5.00 L.E