DOMPIDONE

1-Active Ingredient:
Domperidone

2-Concentration:
*Tablet: Domperidone 10 mg / tablet
* Oral suspension: 1 mg / 1 ml
* Suppositories: 60 mg / supp. For adult
30 mg / supp. For children
10 mg / supp. For babies

3-Dosage form:
*Tablets
* Oral suspension
* Suppositories

4-Indication:
*Acute nausea and vomiting caused by levodopa or bromocriptin administration in Parkinson’s disease.
*Gastro-esophageal reflux.
*Irritable bowel syndrome.

5-Side effect:
*it has been well tolerated in most patients
*neurological side effects
*dry mouth
*transient skin rash or itching
*headache
*thirst
*diarrhea
*very mild nervousness
*Dystonic reactions (rarely in adult and children)


6-Contraindication:
…………….

7-Precautions:
*should not be used whenever gastric motility might be dangerous e.g. (gastrointestinal hemorrhage – mechanical obstruction or perforation)
*It should not be used in patients with hepatic or renal impairment (specialy oral suspension as it contains propylene glycol)
*it should be used for 12 weeks only in patients with Parkinson’s disease
*it can cross the blood-brain barrier so there is risk of central effects so it should only be used in pakinsonian patients when safer anti-emetic measures have failed.

8-Dose:

*Tablets:
-For acute nausea and vomiting: 10 to 20 mg three times daily
-For reflux oesophagitis: 20 mg four times daily
-For reflux chronic gastritis: 30 mg four times daily
-For irritable bowel syndrome: 10 mg three times daily
-For patients with chronic postprandial dyspepsia: 10 mg three times daily 15 to 30 minutes before meals and at bed time if nessacary
- For peptic ulcer treatment: 20 mg three times daily before meals

*Oral suspension for children:
-chronic dyspepsia: 2.5 ml per 10 kg body weight three times daily before meals and one more at the evening if necessary ( if results are not satisfactory he dose should be doubled in children over two years of age )
-nausea and vomiting: 5 ml per 10 kg body weight three times daily before meals and before bed time

*rectal suppositories:
-Adult: 2 to 4 suppositories “adult” (60 mg) per day
-Over 2 years: 2 to 4 suppositories “children” (30 mg) per day
-Up to 2 years: 2 to 4 suppositories “babies” (10 mg) per day

9-Over dose:
…………….

10-Storage:
Store at 25 C

11-Package:
*Oral suspension: glass bottles of 100 ml & 200 ml
*Tablets: box of 30 tablets in strip
*Suppositories:
-Adult: box of 6 suppositories (60 mg / supp.)
-Children: box of 6 suppositories ( 30 mg / supp.)
- Babies: box of 6 suppositories (10 mg / supp.)

12-produced by:
The arab drug company

13-Price:
*Tablet: 6.60 L.E
*Suspension: 4.00 L.E
*suppositories:
-Adult: 9.00 L.
-Children: 5.00 L.E
-Babies: 2.50 L.E